The crash happened on County Road 181 C north of Nancy Darby Road.
The Florida Highway Patrol says 64 year old Charles Bruce Johnson went out of control on a curve and crashed into the side of a car head in the opposite direction.
Troopers say Johnson died at the scene.
The other driver, 35 year old Douglas Alan Sanders of Crestview and his passenger 38 year old Sonny Wayne Smith of Jacksonville are both in serious condition at Bay Medical/Sacred Heart in Panama City.
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