Sheriff's deputies say a couple and their grandchild died in the blaze,.
The victims have been identified as 49 year old Joel William Hatcher, his wife Cathy Hatcher, 45 and their grandson Luke Tolly Johnson who was just several weeks away from turning two years old.
The fire destroyed the family's home on Van Lierop Road off of State Road 69 about four miles north of Blountstown.
The State Fire Marshal and Calhoun County Sheriff's Deputies are still at the scene investigating.
The cause of the late Thursday night fire has not been determined.
The home was destroyed.