PANAMA CITY BEACH - Thousands of bikers have already made their way to Panama City Beach to take part in Thunder Beach.
Police are also investigating the first serious crash involving a biker.
It happened near Pier Park around 9:30 Thursday night.
43 year-old James Pugh of Marietta, Georgia was driving the bike westbound when it left the pavement at the end of the turn lane and drove into the grass.
Officials say Pugh was thrown from the motorcycle, and was not wearing a helmet.
He is in critical condition.