Crist was favored by 50 percent compared to 34 percent who preferred Scott in a survey of 1,000 registered voters conducted March 13-18 by Quinnipiac University.
It also shows that Democrat Alex Sink, who lost to Scott in 2010, ahead of Scott by a margin of 45 percent to 34 percent. The poll's margin of error is plus or minus 3.1 percentage points.
Half of those surveyed said they view Crist's switch from the GOP to the Democratic Party as a sign that he's a pragmatist.
The poll shows Scott would handily defeat Agriculture Commissioner Adam Putnam in a GOP primary.